Stability indicating RP-HPLC method has been developed for the simultaneous estimation of Cilnidipine (CIL) and Olmesartan Medoxomil (OLM) in bulk and its pharmaceutical dosage form. In RP-HPLC method, chromatographic separation was achieved using C18 column (250 mm x 4.6 mm, 5 μm) and 10 mM dipotassium hydrogen phosphate : acetonitrile (60:40 v/v, pH 6.4) as mobile phase at flow rate of 1.0 ml/min with detection wavelength of 254 nm. The linearity of CIL and OLM were found in the range of 80-120 μg/ml and 320-480 μg/ml. Retention times in RP-HPLC method were found to be 4.6 min and 3.2 min for CIL and OLM respectively. The % recoveries were found to be 99.33±0.97 for CIL and 99.67±0.21 for OLM. The proposed method was validated as per ICH guidelines and successfully applied for the determination of drugs in pharmaceutical formulation.
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